With no explanation, label each line with "O", "other-chemicalthing", "art-broadcastprogram", "art-film", "art-music", "art-other", "art-painting", "art-writtenart", "building-airport" or "building-hospital" preceded by ":".
The
active
metabolites
of
spironolactone
have
extended
terminal
half-lives
of
13.8
hours
for
7α-TMS
,
15.0
hours
for
6β-OH-7α-TMS
,
and
16.5
hours
for
canrenone
,
and
accordingly
,
these
metabolites
are
responsible
for
the
therapeutic
effects
of
the
drug
.
The:O
active:O
metabolites:O
of:O
spironolactone:other-chemicalthing
have:O
extended:O
terminal:O
half-lives:O
of:O
13.8:O
hours:O
for:O
7α-TMS:other-chemicalthing
,:O
15.0:O
hours:O
for:O
6β-OH-7α-TMS:other-chemicalthing
,:O
and:O
16.5:O
hours:O
for:O
canrenone:other-chemicalthing
,:other-chemicalthing
and:O
accordingly:O
,:O
these:O
metabolites:O
are:O
responsible:O
for:O
the:O
therapeutic:O
effects:O
of:O
the:O
drug:O
.:O